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Chronic inflammation, driven by immune cell infiltration (macrophages, T cells, B cells) and pro-inflammatory cytokines (IL-1β, TNF-α, IL-6), activates signaling pathways such as NF-κB and MAPK, promoting disc cell apoptosis and extracellular matrix (ECM) degradation (Figure 1)

Anti-Inflammatory Signaling

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These findings may justify further scientific investigation, but they do not demonstrate clinical efficacy