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FIGURE 2 3.3 Hypoxic-glucose deprivation conditions can induce senescence in endothelial cells Unlike the previously mentioned natural aging models and progeria models, there is another common but often overlooked endothelial cell aging model: hypoxia-induced endothelial cell senescence

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16 To examine whether adaptive immune compensation in response to the increased gut permeability in these mice may have affected the overall phenotype, investigators examined the susceptibility of F11r(−/−)Rag1(−/−) mice to acute colitis