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One important aspect of lipid peroxidation is the generation of hydroxyl radicals (OH•), which can be fatal to cells if they accumulate excessively ( Through an array of procedures, ferroptosis contributes to endothelial cell damage as ARDS progresses ( 3.3 Fibroblast The survival controls for ARDS fibroblasts differ from those for healthy lung fibroblasts
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In a one-year follow-up study, elevated serum MDA levels were identified as independent predictors of mortality in CAD patients, supporting the hypothesis that lipid peroxidation contributes to both the development and severity of heart disease (57)