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This hypothesis is supported by post-mortem evidence of reduced pyruvate dehydrogenase activity in the brains of individuals with ASD ( Alongside impairments in carbohydrate metabolism, evidence of reduced carnitine levels suggest a dysfunction in mitochondrial β-oxidation, leading to accumulation of long-chain fatty acids and elevated markers of lipid elongation and desaturation (Pastural et al., 2009)
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Research Applications Our catalog supports controlled laboratory research across areas such as: Cellular Signaling — receptor activity, signaling pathways, and molecular interactions Metabolic Research — metabolic regulation and incretin receptor-signaling models Neurobiology — cognitive, behavioral, and stress-response pathways Immunology — immune signaling and host-response models Tissue Biology — extracellular-matrix signaling, cellular migration, and tissue remodeling research Mitochondrial Biology — cellular energy systems and aging-related pathways Endocrine Research — neuroendocrine and reproductive-axis signaling Pigment Biology — melanogenesis and related cellular pathways Research relevance varies by compound and study design
