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According to data from the literature, significant events in the formation of a stroke area, such as excitotoxicity, mitochondrial damage, emergence of reactive oxygen species, and apoptosis, occur within the first 3 h after occlusion of an artery [53], and the expression of genes at the early stage of ischemia can be studied at this time point

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References Benoist CC, Kawas LH, Zhu M, et al