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Moreover, by targeting inflammatory pathways such as NF-κB and HIF-1, and reducing pro-inflammatory cytokines, mainly IL-6 and TNF-α, these compounds protect against melanocyte loss characteristic of this disorder 150,151

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These mutations in SHP2 result in hyperactive phosphatase activity, notably with elevated basal activity and result in inhibition of GH-induced insulin-like growth factor-1 (IGF-1) production (143, 151)