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Exogenous testosterone supplementation upregulates the expression and activity of PGC-1α protein and enhances skeletal muscle mitochondrial biogenesis and energy expenditure, which eventually alleviates castration-induced mitochondrial dysfunction (83)

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A different isozyme of γ-glutamyltranspeptidase (GGT1) initiates the enzymatic cleavage of extracellular glutathione, leading to the degradation of glutathione to its component amino acids (Hanigan and Ricketts, 1993)