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Taken together, these findings suggest that tretinoin remains the most effective for reducing hyperpigmentation, urea provides a dose-responsive benefit for texture and erythema, salicylic acid can serve as a mild and tolerable alternative, and TCA peel is preferable over glycolic acid when a procedural option is chosen
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GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists
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