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111,112 Mn II plays many diverse roles in biology, 113 including that of Lewis acid in transformations that do not require a change in oxidation state, e.g., in phosphatases, arginase and a number of metabolic enzymes, but also in other contexts where Mn III and higher oxidation states are reached, including Mn-superoxide dismutase, some ribonucleotide reductases, and the oxygen evolving complex in plants

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However, β3-KO mice failed to show any significant changes in body weight following treatment with AOD9604 or hGH