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In one study, one week of kava administration (75 mg/kg) induced an increase in acetylcholinesterase (AchE) activity in the adult male rat striatum [85], while 4-week administration resulted in significant decreases in the enzymatic activity in the cortex, hippocampus, and striatum [85]

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We generally recommend that patients avoid driving for at least 4-6 hours following Benadryl IV therapy due to its potential sedative effects