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Topical formulations at 0.5-2% have shown some efficacy in controlled settings, but DIY reconstitution from raw powder introduces contamination, stability, and bioavailability variables that no peer-reviewed protocol has validated for home use

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Baseline visit: CBC, CMP, and documented written informed consent before any injection Week 2 check-in: Assess tolerability, review injection technique compliance, and address any early adverse effects Week 4 mid-cycle reassessment: Evaluate clinical response using validated outcome tools such as VAS pain scores and functional movement assessments End-of-cycle review: Decide on continuation, dose adjustment, or discontinuation based on objective findings Relying solely on subjective patient reporting is inadequate