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Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth

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A subsequent 2-month open-label phase of a randomized placebo-controlled trial of adjunctive oral NAC 1 g twice daily in 149 patients with moderate bipolar depression showed robust improvement in BDRS, quality of life, and functioning [152]