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HF-fed rats from the HF + Met and HF + L-car groups received oral gavage of L-car (HY-B0399, C 7 H 15 NO 3 , purity: ≥98.0%, 200 mg/kg, MedChemExpress, Monmouth Junction, NJ, USA) and Met (HY-B0627, C 4 H 11 N 5 , purity: 99.64%, 100 mg/kg, MedChemExpress, USA) once daily, respectively, for 4 weeks [24]