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The three most effective (semaglutide, tirzepatide, retatrutide) are GLP-1 agonists: they mimic a natural gut hormone that tells your brain you are full

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Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake