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Dysregulation of the hypothalamic–pituitary-ovarian axis, driven by increased LH secretion, stimulates theca cell hyperplasia and enhances the expression of enzymes critical for androgen biosynthesis, thereby promoting excessive androgen production (10)

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This is characterized by significantly increased blood levels of C-reactive protein and other pro-inflammatory factors, such as IL-1β, IL-6, and TNF-α, accompanied by decreases in anti-inflammatory factors, including IL-5 and IL-10