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Administration of Withanolide A alongwith exogenous corticosterone supplementation to the normoxic group decrease the Nrf2 as well as GCLC expression while inhibition of corticosterone synthesis using metyrapone reverses hypoxia induced downregulation of both Nrf2 and GCLC level

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Mice in the Con group were fed a control diet [11 kcal% fat w/cornstarch Surwit Diet (D12328, lot number: 17100212A4, Research Diets)] and normal water