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Our finding that CMS4 is overrepresented in PM sheds new light on the recently published results of the PRODIGE7 study, demonstrating a lack of benefit of intraperitoneal oxaliplatin treatment following cytoreductive surgery for PM [10]
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The trade-off is that Tesamorelin’s approval is narrow: it applies specifically to HIV-associated lipodystrophy, not general fat loss, and its GH-axis mechanism carries monitoring requirements around IGF-1 and glucose that AOD-9604’s trials did not show