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Abbreviations 4E-BP1 Eukaryotic translation initiation factor 4E-binding protein-1 6W Six-minute walk test AEs Adverse events BMI Body mass index Comp Composite endpoint DXA Dual-energy X-ray absorptiometry ITT Intent-to-treat LS Lower strength MM Muscle mass mTOR Mammalian target of rapamycin MuRF1 Muscle RING-finger protein-1 NNHPD Natural and non-prescription health products directorate NSAID Non-steroidal anti-inflammatory drug PP Per-protocol QoL Quality of life S6K p70-S6 kinase UPS Ubiquitin–proteasome system US Upper strength Additional file Contributor Information Malkanthi Evans, Email: [email protected]