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76,77 Although Zn II -removal increases the rate of protein degradation in bacterial cells in an MBL-specific way, 77 recent data for NDMs suggest that this picture is far more complex, with recently arising mutations linked to an enhanced kinetic and conformational stability and therefore increased lifetime of the β-lactamase in the periplasm, i.e., the proteostasis network (Figure 1), with Zn II affinity just one, albeit important aspect of this evolution
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