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[DOI] [PubMed] [Google Scholar] [150].Lenhardt S, McAlexander A, Virtue A, Fieles W, Skedzielewski T, Rambo M, Trinh H, Cheng S-H, Hong H, Isidro-Llobet A, Nadin A, Geske R, Klein J-L, Lee D, Jucker BM, Hu E, In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice, Journal of Pharmacology and Experimental Therapeutics, (2019) jpet.119.257022

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Because tyrosine differs from phenylalanine by a single hydroxyl group, AOD9604 and the unmodified 176-191 sequence are both 16-residue peptides that differ by exactly one oxygen atom — 1,815.1 g/mol versus 1,799.1 g/mol