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Additional evidence of systemic inflammation effecting the CNS is seen in a mouse model of intraperitoneal LPS injection, which revealed morphological changes in microglia after 3 h, suggestive of an activated state, that persisted up to one week post injection (Yang et al., 2013)
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The GABAA receptor is a ligand-gated chloride (Cl - ) channel, composed of five subunits arranged around a central pore, forming a heteropentameric transmembrane glycoprotein structure embedded in the neuronal membrane ( - channel, allowing Cl - ions to flow into the cell along their concentration gradient
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