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These studies revealed that DSePA was not an efficient GPx mimic and its ability to catalyze the detoxification of hydroperoxides through the GPx cycle was considerably lower than ebselen [82, 83]

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A different isozyme of γ-glutamyltranspeptidase (GGT1) initiates the enzymatic cleavage of extracellular glutathione, leading to the degradation of glutathione to its component amino acids (Hanigan and Ricketts, 1993)