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Key signs of final-stage spinal stenosis: Severe back and leg pain Stiffness and reduced mobility Numbness, weakness, and tingling Foot drop Balance problems When to go to the ER: Sudden, rapidly progressing numbness, tingling, or weakness Loss of bladder or bowel function Numbness in the inner thighs, buttocks, perineum (saddle anesthesia) Sudden inability to stand or walk What is Spinal Stenosis

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What dosing protocol was used in the landmark FOXO4-DRI mouse study