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Since September 29, 2023 the FDA has listed it in Category 2 of its compounding bulk substances list, the category for substances with identified significant safety risks, and in July 2026 the agency proposed that it not be added to the list pharmacies may compound

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Fluoride in bottled water may be coming from natural sources or, for the bottled water brands that use tap water, fluoride may originate from municipal water treatment (FDA 2008b)