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216 Mutations relevant to ASD typically sensitize voltage-dependent Ca 2+ channel gating, shifting their activation to more hyperpolarized potentials of ~10 mV

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Tirzepatide has also shown liver fat reduction in clinical trials (up to 53% reduction in the Combined effect-NASH trial), but survodutide's Phase 2 MASH data showed 83% relative liver fat reduction at the highest dose, suggesting a meaningful efficacy advantage for hepatic steatosis specifically