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Based on current advancements in oxidative stress research in breast cancer, we propose several innovative therapeutic approaches targeting the ROS–PCD network for future development: (1) Oxidative stress-directed small-molecule drugs: Natural compounds such as curcumin can induce apoptosis by triggering mitochondrial ROS bursts and DNA damage while enhancing ferroptosis sensitivity through GPX4 inhibition

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Glutathione helps prevent this by neutralizing these harmful molecules