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The epigenetic durability of these gene expression changes (i.e., whether they persist after drug discontinuation) is a key question that may determine whether semaglutide can produce lasting metabolic reprogramming or whether its effects are entirely reversible

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[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Xu B., Liang S., Zhao J., Li X., Guo J., Xin B., Li B., Huo G., Ma W