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Discussion: This work establishes a mechanistic foundation for integrating evidence-based nutraceuticals—particularly myo-inositol, probiotics, and omega-3s—into PCOS management, offering clinically actionable strategies while highlighting needs for standardized dosing and bioavailability studies

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The study randomized 2,339 adults with obesity or overweight to receive retatrutide 4 mg, 9 mg, 12 mg, or placebo