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The GSH/GSSG ratio is a useful measurement for determining oxidative stress [74] and changes in this ratio appear to correlate with cell proliferation [75], differentiation [76] and apoptosis [77]

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To isolate the effects of IGF-1 on target tissues without the influence of IGF-binding proteins, recombinant long arginine 3 IGF-1 (IGF-1 LR3) is commonly used in animal models and has been shown to increase growth in fetal sheep (24–26)