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[ 9 , 10 ] However, despite decades of investigation, much of the available evidence comes from laboratory studies, animal models, or relatively small human trials

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Interestingly, we found increased interstitial fibrosis and vascular abnormalities consistent with inflammation and fibrosis in coronary and aortic sections from older GPx1 +/− mice [39], illustrating the detrimental effects of chronic oxidative stress on the vasculature